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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730944
Species: Homo sapiens
RGD Object: Gene
Symbol: ABCB11
Name: ATP binding cassette subfamily B member 11
Acc ID: CHEBI:119486
Term: efavirenz
Definition: 1,4-Dihydro-2H-3,1-benzoxazin-2-one substituted at the 4 position by cyclopropylethynyl and trifluoromethyl groups (S configuration) and at the 6 position by chlorine. A non-nucleoside reverse transcriptase inhibitor with activity against HIV, it is used with other antiretrovirals for combination therapy of HIV infection.
Chemical ID: MESH:C098320
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ABCB11decreases activityEXP 6480464CTDefavirenz results in decreased activity of ABCB11 proteinPMID:24014644
ABCB11multiple interactionsEXP 6480464CTDefavirenz inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]PMID:24014644
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