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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2898
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il4
Name: interleukin 4
Acc ID: CHEBI:119
Term: D-synephrine
Definition: The D-enantiomer of synephrine.
Chemical ID: MESH:D013578
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:107966480464CTDSynephrine inhibits the reaction [IL4 protein results in increased expression of and results in increased secretion of CCL11 protein], Synephrine inhibits the reaction [IL4 protein results in increased expression of CCL11 mRNA], Synephrine inhibits the reaction [IL4 protein results in increased phosphorylation of STAT6 protein]

PMID:25111027
multiple interactionsISORGD:7363066480464CTDSynephrine inhibits the reaction [IL4 protein results in increased expression of and results in increased secretion of CCL11 protein]

PMID:25111027
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.