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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731748
Species: Homo sapiens
RGD Object: Gene
Symbol: JAK2
Name: Janus kinase 2
Acc ID: CHEBI:113532
Term: thymoquinone
Definition: A member of the class of 1,4-benzoquinones that is 1,4-bezoquinone in which the hydrogens at positions 2 and 5 are replaced by methyl and isopropyl groups, respectively. It is a natural compound isolated from Nigella sativa which has demonstrated promising chemotherapeutic activity.
Chemical ID: MESH:C003466
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
JAK2decreases phosphorylationEXP 6480464CTDthymoquinone results in decreased phosphorylation of JAK2 proteinPMID:34627931
JAK2multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [thymoquinone results in decreased phosphorylation of JAK2 protein]PMID:34627931
JAK2decreases phosphorylationISOJak2 (Mus musculus)6480464CTDthymoquinone results in decreased phosphorylation of JAK2 proteinPMID:34605108
JAK2multiple interactionsISOJak2 (Mus musculus)6480464CTDDoxorubicin promotes the reaction [thymoquinone results in decreased phosphorylation of JAK2 protein]; thymoquinone inhibits the reaction [Doxorubicin results in increased phosphorylation of JAK2 protein]PMID:34605108
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