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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621455
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Twist1
Name: twist family bHLH transcription factor 1
Acc ID: CHEBI:113532
Term: thymoquinone
Definition: A member of the class of 1,4-benzoquinones that is 1,4-bezoquinone in which the hydrogens at positions 2 and 5 are replaced by methyl and isopropyl groups, respectively. It is a natural compound isolated from Nigella sativa which has demonstrated promising chemotherapeutic activity.
Chemical ID: MESH:C003466
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Twist1decreases expressionISOTWIST1 (Homo sapiens)6480464CTDthymoquinone results in decreased expression of TWIST1 proteinPMID:27060453 PMID:35774120
Twist1multiple interactionsISOTWIST1 (Homo sapiens)6480464CTDpyrazolanthrone inhibits the reaction [thymoquinone results in decreased expression of TWIST1 protein]; SB 203580 inhibits the reaction [thymoquinone results in decreased expression of TWIST1 protein]; thymoquinone promotes the reaction [cordycepin results in decreased expression of TWIST1 protein]PMID:27060453 PMID:35774120
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