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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2053
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Parp1
Name: poly (ADP-ribose) polymerase 1
Acc ID: CHEBI:113532
Term: thymoquinone
Definition: A member of the class of 1,4-benzoquinones that is 1,4-bezoquinone in which the hydrogens at positions 2 and 5 are replaced by methyl and isopropyl groups, respectively. It is a natural compound isolated from Nigella sativa which has demonstrated promising chemotherapeutic activity.
Chemical ID: MESH:C003466
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Parp1increases cleavageISOPARP1 (Homo sapiens)6480464CTDthymoquinone results in increased cleavage of PARP1 proteinPMID:29981725 PMID:31298468 PMID:34627931
Parp1increases expressionISOPARP1 (Homo sapiens)6480464CTDthymoquinone results in increased expression of PARP1 protein modified formPMID:31433961
Parp1multiple interactionsISOPARP1 (Homo sapiens)6480464CTD4-phenylbutyric acid inhibits the reaction [thymoquinone results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [thymoquinone results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [thymoquinone results in increased expression of PARP1 protein modified form]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [thymoquinone results in increased activity of PARP1 protein]; DDIT3 protein affects the reaction [thymoquinone results in increased cleavage of PARP1 protein]PMID:29981725 PMID:31433961 PMID:34627931
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