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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1604618
Species: Homo sapiens
RGD Object: Gene
Symbol: CYCS
Name: cytochrome c, somatic
Acc ID: CHEBI:113532
Term: thymoquinone
Definition: A member of the class of 1,4-benzoquinones that is 1,4-bezoquinone in which the hydrogens at positions 2 and 5 are replaced by methyl and isopropyl groups, respectively. It is a natural compound isolated from Nigella sativa which has demonstrated promising chemotherapeutic activity.
Chemical ID: MESH:C003466
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYCSincreases expressionEXP 6480464CTDthymoquinone results in increased expression of CYCS proteinPMID:31433961
CYCSmultiple interactionsISOCycs (Mus musculus)6480464CTDthymoquinone inhibits the reaction [Benzo(a)pyrene results in decreased expression of CYCS protein]PMID:36193556
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