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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734192
Species: Mus musculus
RGD Object: Gene
Symbol: Gpt
Name: glutamic pyruvic transaminase, soluble
Acc ID: CHEBI:110423
Term: clodronic acid
Definition: An organochlorine compound that is methylene chloride in which both hydrogens are replaced by phosphonic acid groups. It inhibits bone resorption and soft tissue calcification, and is used (often as the disodium salt tetrahydrate) as an adjunct in the treatment of severe hypercalcaemia associated with malignancy, and in the management of osteolytic lesions and bone pain associated with skeletal metastases.
Chemical ID: MESH:D004002
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gptmultiple interactionsEXP 6480464CTDClodronic Acid inhibits the reaction [PTEN gene mutant form results in increased secretion of GPT protein]; Clodronic Acid promotes the reaction [Acetaminophen results in increased activity of GPT protein]PMID:27022031 PMID:34724096
Gptmultiple interactionsISOGpt (Rattus norvegicus)6480464CTDClodronic Acid promotes the reaction [Thioacetamide results in increased expression of GPT protein]PMID:26957569
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