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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1605110
Species: Homo sapiens
RGD Object: Gene
Symbol: KEAP1
Name: kelch like ECH associated protein 1
Acc ID: CHEBI:110423
Term: clodronic acid
Definition: An organochlorine compound that is methylene chloride in which both hydrogens are replaced by phosphonic acid groups. It inhibits bone resorption and soft tissue calcification, and is used (often as the disodium salt tetrahydrate) as an adjunct in the treatment of severe hypercalcaemia associated with malignancy, and in the management of osteolytic lesions and bone pain associated with skeletal metastases.
Chemical ID: MESH:D004002
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
KEAP1increases expressionEXP 6480464CTDClodronic Acid results in increased expression of KEAP1 mRNAPMID:25596134
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