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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2254
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Calca
Name: calcitonin-related polypeptide alpha
Acc ID: CHEBI:10650
Term: sumatriptan
Definition: A sulfonamide that consists of N,N-dimethyltryptamine bearing an additional (N-methylsulfamoyl)methyl substituent at position 5. Selective agonist for a vascular 5-HT1 receptor subtype (probably a member of the 5-HT1D family). Used (in the form of its succinate salt) for the acute treatment of migraine with or without aura in adults.
Chemical ID: MESH:D018170
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Calcadecreases expressionEXP 6480464CTDSumatriptan results in decreased expression of CALCA mRNA

PMID:14715155
Calcamultiple interactionsEXP 6480464CTD3-3-dimethylaminopropyl-4-hydroxy-N-4-4-pyridinylphenylbenzamide inhibits the reaction [Sumatriptan results in decreased expression of CALCA mRNA] [Sumatriptan results in increased abundance of Calcium] inhibits the reaction [MAP2K1 protein results in increased expression of CALCA mRNA] GR 127935 inhibits the reaction [Sumatriptan results in decreased expression of CALCA mRNA] isamoltane inhibits the reaction [Sumatriptan results in decreased expression of CALCA mRNA] Sumatriptan inhibits the reaction [MAP2K1 protein results in increased expression of CALCA mRNA] Sumatriptan inhibits the reaction [NGF protein results in increased expression of CALCA mRNA]

PMID:12574409 PMID:14715155
Calcamultiple interactionsISORGD:7309926480464CTDSumatriptan results in decreased expression of and results in decreased secretion of CALCA protein

PMID:15689192
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