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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731305
Species: Homo sapiens
RGD Object: Gene
Symbol: NTRK2
Name: neurotrophic receptor tyrosine kinase 2
Acc ID: CHEBI:104872
Term: rolipram
Definition: A member of the lclass of pyrrolidin-2-ones that is pyrrolidin-2-one bearing a 3-(cyclopentyloxy)-4-methoxyphenyl substituent at the 4-position. It is a type IV-specific phosphodiesterase (PDE4) inhibitor.
Chemical ID: MESH:D020889
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NTRK2increases expressionISONtrk2 (Rattus norvegicus)6480464CTDRolipram results in increased expression of NTRK2 mRNAPMID:8601816
NTRK2multiple interactionsISONtrk2 (Mus musculus)6480464CTDRolipram inhibits the reaction [NTRK2 protein binds to AP2M1 protein]PMID:31631060
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