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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10331
Species: Mus musculus
RGD Object: Gene
Symbol: Cftr
Name: cystic fibrosis transmembrane conductance regulator
Acc ID: CHEBI:104872
Term: rolipram
Definition: A member of the lclass of pyrrolidin-2-ones that is pyrrolidin-2-one bearing a 3-(cyclopentyloxy)-4-methoxyphenyl substituent at the 4-position. It is a type IV-specific phosphodiesterase (PDE4) inhibitor.
Chemical ID: MESH:D020889
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cftrdecreases activityISOCFTR (Homo sapiens)6480464CTDRolipram results in decreased activity of CFTR proteinPMID:15611099
Cftrincreases activityISOCFTR (Homo sapiens)6480464CTDRolipram results in increased activity of CFTR proteinPMID:12714375
Cftrmultiple interactionsISOCFTR (Homo sapiens)6480464CTDRolipram promotes the reaction [CFTR protein affects the secretion of Chlorides]PMID:12714375
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