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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730947
Species: Mus musculus
RGD Object: Gene
Symbol: Crh
Name: corticotropin releasing hormone
Acc ID: CHEBI:10415
Term: beta-endorphin
Definition: A polypeptide consisting of 31 amino acid residues in the sequence Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys-Asn-Ala-Ile-Ile-Lys-Asn-Ala-Tyr-Lys-Lys-Gly-Glu. It is an endogenous opioid peptide neurotransmitter found in the neurons of both the central and peripheral nervous system and results from processing of the precursor protein proopiomelanocortin (POMC).
Chemical ID: MESH:D001615
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Crhdecreases secretionISOCrh (Rattus norvegicus)6480464CTDbeta-Endorphin results in decreased secretion of CRH proteinPMID:3031743
Crhincreases secretionISOCrh (Rattus norvegicus)6480464CTDCRF protein results in increased secretion of beta-EndorphinPMID:1480515
Crhmultiple interactionsISOCrh (Rattus norvegicus)6480464CTDadinazolam inhibits the reaction [CRF protein results in increased secretion of beta-Endorphin]; beta-Endorphin inhibits the reaction [Nitroprusside results in increased secretion of CRH protein]; Naltrexone inhibits the reaction [beta-Endorphin results in decreased secretion of CRH protein]PMID:1480515 PMID:3031743
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