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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1549990
Species: Mus musculus
RGD Object: Gene
Symbol: Chat
Name: choline acetyltransferase
Acc ID: CHEBI:10138
Term: [6]-Shogaol
Definition: A monomethoxybenzene that has formula C17H24O3.
Chemical ID: MESH:C040115
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chatincreases expressionEXP 6480464CTD[shogaol results in increased expression of BDNF protein] which results in increased expression of CHAT protein; shogaol results in increased expression of CHAT proteinPMID:22381256
Chatmultiple interactionsEXP 6480464CTD[shogaol co-treated with Hydrogen Peroxide] results in increased expression of CHAT protein; shogaol inhibits the reaction [Hydrogen Peroxide results in decreased expression of CHAT protein]; staurosporine aglycone inhibits the reaction [[shogaol co-treated with Hydrogen Peroxide] results in increased expression of CHAT protein]PMID:22381256
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