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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733100
Species: Homo sapiens
RGD Object: Gene
Symbol: BCL2
Name: BCL2 apoptosis regulator
Acc ID: CHEBI:10136
Term: gingerol
Definition: A beta-hydroxy ketone that is 5-hydroxydecan-3-one substituted by a 4-hydroxy-3-methoxyphenyl moiety at position 1; believed to inhibit adipogenesis. It is a constituent of fresh ginger.
Chemical ID: MESH:C007845
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BCL2multiple interactionsISOBcl2 (Mus musculus)155882488RGDgingerol inhibits the reaction [hypoxia-reoxygenation decreases expression of Bcl2 protein in neural crest-derived cells] 
BCL2decreases expressionEXP 6480464CTDgingerol results in decreased expression of BCL2 mRNA; gingerol results in decreased expression of BCL2 proteinPMID:18030663 PMID:19481070 PMID:25034532 PMID:28249781
BCL2multiple interactionsEXP 6480464CTD[gingerol co-treated with Hydrogen Peroxide] results in increased expression of BCL2 protein; Acetylcysteine inhibits the reaction [gingerol results in decreased expression of BCL2 protein]; gingerol inhibits the reaction [Testosterone results in increased expression of BCL2 protein]PMID:18030663 PMID:25034532 PMID:27451028
BCL2multiple interactionsISOBcl2 (Mus musculus)6480464CTDgingerol inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of BCL2 protein]; gingerol inhibits the reaction [Testosterone results in increased expression of BCL2 protein]; gingerol inhibits the reaction [TNF protein results in decreased expression of BCL2 protein]PMID:18030663 PMID:37121058
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