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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2326
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cebpa
Name: CCAAT/enhancer binding protein alpha
Acc ID: CHEBI:10136
Term: gingerol
Definition: A beta-hydroxy ketone that is 5-hydroxydecan-3-one substituted by a 4-hydroxy-3-methoxyphenyl moiety at position 1; believed to inhibit adipogenesis. It is a constituent of fresh ginger.
Chemical ID: MESH:C007845
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:103256480464CTDgingerol results in decreased expression of CEBPA mRNA, gingerol results in decreased expression of CEBPA protein

PMID:26498061
multiple interactionsISORGD:103256480464CTDGSK3B protein promotes the reaction [gingerol results in decreased expression of CEBPA mRNA], GSK3B protein promotes the reaction [gingerol results in decreased expression of CEBPA protein]

PMID:26498061
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.