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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730995
Species: Homo sapiens
RGD Object: Gene
Symbol: HSF1
Name: heat shock transcription factor 1
Acc ID: CHEBI:101278
Term: diltiazem
Definition: A 5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate in which both stereocentres have S configuration. A calcium-channel blocker and vasodilator, it is used as the hydrochloride in the management of angina pectoris and hypertension.
Chemical ID: MESH:D004110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HSF1decreases activityEXP 6480464CTDDiltiazem results in decreased activity of HSF1 proteinPMID:34170685
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