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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10230
Species: Mus musculus
RGD Object: Gene
Symbol: Bcl2
Name: B cell leukemia/lymphoma 2
Acc ID: CHEBI:10110
Term: zidovudine
Definition: A pyrimidine 2',3'-dideoxyribonucleoside compound having a 3'-azido substituent and thymine as the nucleobase.
Chemical ID: MESH:D015215
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2multiple interactionsEXP 6480464CTD[Zidovudine co-treated with Lamivudine] results in decreased expression of BCL2 mRNAPMID:18313992
Bcl2affects response to substanceISOBCL2 (Homo sapiens)6480464CTDBCL2 protein affects the susceptibility to ZidovudinePMID:9850737
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDZidovudine results in decreased expression of BCL2 mRNAPMID:17696246
Bcl2increases expressionISOBcl2 (Rattus norvegicus)6480464CTDZidovudine results in increased expression of BCL2 mRNAPMID:29594326
Bcl2increases expressionISOBCL2 (Homo sapiens)6480464CTDZidovudine results in increased expression of BCL2 mRNAPMID:9850737
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTDDrugs, Chinese Herbal promotes the reaction [Zidovudine results in decreased expression of BCL2 mRNA]PMID:17696246
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