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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731081
Species: Homo sapiens
RGD Object: Gene
Symbol: PGR
Name: progesterone receptor
Acc ID: CHEBI:10106
Term: zearalenone
Definition: A macrolide comprising a fourteen-membered lactone fused to 1,3-dihydroxybenzene; a potent estrogenic metabolite produced by some Giberella species.
Chemical ID: MESH:D015025
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDZearalenone results in increased expression of PGR mRNA, Zearalenone results in increased expression of PGR protein

PMID:19371625, PMID:21803136, PMID:28807876, PMID:28965971
multiple interactionsEXP 6480464CTDfulvestrant inhibits the reaction [Zearalenone results in increased expression of PGR protein], Zearalenone inhibits the reaction [Progesterone binds to and results in increased activity of PGR protein]

PMID:21803136
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.