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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3046
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk3
Name: mitogen activated protein kinase 3
Acc ID: CHEBI:10106
Term: zearalenone
Definition: A macrolide comprising a fourteen-membered lactone fused to 1,3-dihydroxybenzene; a potent estrogenic metabolite produced by some Giberella species.
Chemical ID: MESH:D015025
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk3decreases phosphorylationEXP 6480464CTDZearalenone results in decreased phosphorylation of MAPK3 proteinPMID:32858132
Mapk3decreases phosphorylationISOMapk3 (Mus musculus)6480464CTDZearalenone results in decreased phosphorylation of MAPK3 proteinPMID:30394307
Mapk3multiple interactionsISOMapk3 (Mus musculus)6480464CTDHERPUD1 protein promotes the reaction [Zearalenone results in decreased phosphorylation of MAPK3 protein]PMID:30394307
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