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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 14261254
Species: Sus scrofa
RGD Object: Gene
Symbol: IGF1
Name: insulin like growth factor 1
Acc ID: CHEBI:10106
Term: zearalenone
Definition: A macrolide comprising a fourteen-membered lactone fused to 1,3-dihydroxybenzene; a potent estrogenic metabolite produced by some Giberella species.
Chemical ID: MESH:D015025
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IGF1decreases expressionEXP 6480464CTDZearalenone results in decreased expression of IGF1 mRNA; Zearalenone results in decreased expression of IGF1 proteinPMID:29758222
IGF1multiple interactionsEXP 6480464CTDZearalenone affects the reaction [IGF1 protein results in increased abundance of Estradiol]; Zearalenone inhibits the reaction [[FSHB protein co-treated with IGF1 protein] results in increased expression of CYP11A1 mRNA]; Zearalenone inhibits the reaction [[FSHB protein co-treated with IGF1 protein] results in increased expression of CYP19A1 mRNA]; Zearalenone promotes the reaction [IGF1 protein results in increased abundance of Progesterone]PMID:17656051
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