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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 14098222
Species: Sus scrofa
RGD Object: Gene
Symbol: IL6
Name: interleukin 6
Acc ID: CHEBI:10106
Term: zearalenone
Definition: A macrolide comprising a fourteen-membered lactone fused to 1,3-dihydroxybenzene; a potent estrogenic metabolite produced by some Giberella species.
Chemical ID: MESH:D015025
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL6increases expressionEXP 6480464CTDZearalenone results in increased expression of IL6 mRNA; Zearalenone results in increased expression of IL6 proteinPMID:23688591 PMID:32783910 PMID:34933075
IL6multiple interactionsEXP 6480464CTD[deoxynivalenol co-treated with nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of IL6 mRNA; [deoxynivalenol co-treated with nivalenol co-treated with Zearalenone] results in increased expression of IL6 mRNA; [deoxynivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of IL6 mRNA; [deoxynivalenol co-treated with Zearalenone] results in increased expression of IL6 mRNA; [nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of IL6 mRNA; [nivalenol co-treated with Zearalenone] results in decreased expression of IL6 mRNA; [nivalenol co-treated with Zearalenone] results in increased expression of IL6 mRNA; [Zearalenone co-treated with fumonisin B1] results in increased expression of IL6 mRNA; deoxynivalenol promotes the reaction [Zearalenone results in increased expression of IL6 protein]; Zearalenone promotes the reaction [deoxynivalenol results in increased expression of IL6 protein]PMID:23688591 PMID:32783910
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