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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731069
Species: Mus musculus
RGD Object: Gene
Symbol: Chrm1
Name: cholinergic receptor, muscarinic 1, CNS
Acc ID: CHEBI:10056
Term: xanomeline
Definition: A tetrahydropyridine that has formula C14H23N3OS.
Chemical ID: MESH:C075257
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chrm1increases response to substanceEXP 6480464CTDCHRM1 gene results in increased susceptibility to xanomeline; CHRM1 results in increased susceptibility to xanomelinePMID:19111716 PMID:19996296
Chrm1multiple interactionsISOChrm1 (Rattus norvegicus)6480464CTDxanomeline binds to and results in increased activity of [CHRM1 protein binds to CHRM4 protein]PMID:21211109
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