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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732487
Species: Homo sapiens
RGD Object: Gene
Symbol: TGM2
Name: transglutaminase 2
Acc ID: CHEBI:10033
Term: warfarin
Definition: A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.
Chemical ID: MESH:D014859
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TGM2affects response to substanceISOTgm2 (Mus musculus)6480464CTD[TGM2 protein affects the susceptibility to Warfarin] which affects the susceptibility to Quercetin; TGM2 protein affects the susceptibility to WarfarinPMID:23117658
TGM2increases response to substanceISOTgm2 (Mus musculus)6480464CTDTGM2 protein results in increased susceptibility to WarfarinPMID:23117658
TGM2multiple interactionsISOTgm2 (Rattus norvegicus)6480464CTD[Warfarin co-treated with Vitamin K] results in increased expression of and results in increased activity of TGM2 protein; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of and results in increased activity of TGM2 protein]; Quercetin inhibits the reaction [Warfarin results in increased activity of TGM2 protein]; Warfarin results in increased expression of and results in increased activity of TGM2 proteinPMID:23117658
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