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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69271
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tcf4
Name: transcription factor 4
Acc ID: CHEBI:10033
Term: warfarin
Definition: A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.
Chemical ID: MESH:D014859
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tcf4increases expressionEXP 6480464CTDWarfarin results in increased expression of TCF4 mRNAPMID:23117658
Tcf4multiple interactionsEXP 6480464CTD[Warfarin co-treated with Vitamin K] results in increased expression of TCF4 mRNA; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of TCF4 mRNA]; Quercetin inhibits the reaction [Warfarin results in increased expression of TCF4 mRNA]PMID:23117658
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