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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731002
Species: Homo sapiens
RGD Object: Gene
Symbol: CASP3
Name: caspase 3
Acc ID: CHEBI:100241
Term: ciprofloxacin
Definition: A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.
Chemical ID: MESH:D002939
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CASP3increases activityEXP 6480464CTDCiprofloxacin results in increased activity of CASP3 proteinPMID:11832715 PMID:11875713 PMID:12632069
CASP3multiple interactionsEXP 6480464CTDCiprofloxacin results in increased cleavage of and results in increased activity of CASP3 proteinPMID:10741713
CASP3increases activityISOCasp3 (Rattus norvegicus)6480464CTDCiprofloxacin results in increased activity of CASP3 proteinPMID:30273099
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