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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735336
Species: Mus musculus
RGD Object: Gene
Symbol: Akt1
Name: thymoma viral proto-oncogene 1
Acc ID: CHEBI:10022
Term: deoxynivalenol
Definition: A trichothecene mycotoxin produced by Fusarium to which wheat, barley, maize (corn) and their products are susceptible to contamination.
Chemical ID: MESH:C007262
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akt1decreases phosphorylationEXP 6480464CTDdeoxynivalenol results in decreased phosphorylation of AKT1 proteinPMID:34506767
Akt1increases phosphorylationEXP 6480464CTDdeoxynivalenol results in increased phosphorylation of AKT1 proteinPMID:16424113 PMID:24937323
Akt1multiple interactionsEXP 6480464CTDAKT1 protein affects the reaction [deoxynivalenol results in increased expression of IL6 mRNA]; AKT1 protein affects the reaction [deoxynivalenol results in increased phosphorylation of CREB1 protein]; deoxynivalenol results in increased phosphorylation of and results in increased activity of AKT1 protein; Docosahexaenoic Acids inhibits the reaction [deoxynivalenol results in increased phosphorylation of AKT1 protein]; lauric acid inhibits the reaction [deoxynivalenol results in decreased phosphorylation of AKT1 protein]PMID:15976193 PMID:16424113 PMID:34506767
Akt1multiple interactionsISOAKT1 (Homo sapiens)6480464CTD[Zearalenone co-treated with deoxynivalenol] results in decreased phosphorylation of AKT1 proteinPMID:35090964
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