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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68640
Species: Homo sapiens
RGD Object: Gene
Symbol: IGFALS
Name: insulin like growth factor binding protein acid labile subunit
Acc ID: CHEBI:10022
Term: deoxynivalenol
Definition: A trichothecene mycotoxin produced by Fusarium to which wheat, barley, maize (corn) and their products are susceptible to contamination.
Chemical ID: MESH:C007262
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IGFALSdecreases expressionISOIgfals (Mus musculus)6480464CTDdeoxynivalenol results in decreased expression of IGFALS mRNA; deoxynivalenol results in decreased expression of IGFALS proteinPMID:19625342 PMID:19805407 PMID:23298694
IGFALSincreases expressionISOIgfals (Rattus norvegicus)6480464CTDdeoxynivalenol results in increased expression of IGFALS mRNAPMID:32738333
IGFALSmultiple interactionsISOIgfals (Mus musculus)6480464CTDdeoxynivalenol inhibits the reaction [Glutathione results in increased expression of IGFALS mRNA]PMID:19805407
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