Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3771
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Stat1
Name: signal transducer and activator of transcription 1
Acc ID: CHEBI:10022
Term: deoxynivalenol
Definition: A trichothecene mycotoxin produced by Fusarium to which wheat, barley, maize (corn) and their products are susceptible to contamination.
Chemical ID: MESH:C007262
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:7321856480464CTDdeoxynivalenol results in increased expression of STAT1 mRNA

PMID:22454431
increases phosphorylationISORGD:7321856480464CTDdeoxynivalenol results in increased phosphorylation of STAT1 protein

PMID:22454431
multiple interactionsISORGD:7321856480464CTD[deoxynivalenol results in increased susceptibility to Antigens] which results in increased expression of STAT1 mRNA, alpha-cyano-(3, 4-dihydroxy)-N-benzylcinnamide inhibits the reaction [deoxynivalenol results in increased expression of STAT1 mRNA], alpha-cyano-(3, 4-dihydroxy)-N-benzylcinnamide inhibits the reaction [deoxynivalenol results in increased phosphorylation of STAT1 protein], stattic inhibits the reaction [deoxynivalenol results in increased expression of STAT1 mRNA], stattic inhibits the reaction [deoxynivalenol results in increased phosphorylation of STAT1 protein]

PMID:22454431, PMID:28935500
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.