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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 14244462
Species: Sus scrofa
RGD Object: Gene
Symbol: CXCL8
Name: C-X-C motif chemokine ligand 8
Acc ID: CHEBI:10022
Term: deoxynivalenol
Definition: A trichothecene mycotoxin produced by Fusarium to which wheat, barley, maize (corn) and their products are susceptible to contamination.
Chemical ID: MESH:C007262
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CXCL8decreases expressionEXP 6480464CTDdeoxynivalenol results in decreased expression of CXCL8 protein

PMID:26417708
CXCL8increases expressionEXP 6480464CTDdeoxynivalenol results in increased expression of CXCL8 mRNA deoxynivalenol results in increased expression of CXCL8 protein

PMID:23326479 PMID:23688591 PMID:25701311 PMID:27915442
CXCL8multiple interactionsEXP 6480464CTD[deoxynivalenol co-treated with fumonisin B1] results in increased expression of CXCL8 mRNA [deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of CXCL8 mRNA [deoxynivalenol co-treated with nivalenol co-treated with fumonisin B1] results in increased expression of CXCL8 mRNA [deoxynivalenol co-treated with nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of CXCL8 mRNA [deoxynivalenol co-treated with nivalenol co-treated with Zearalenone] results in increased expression of CXCL8 mRNA [deoxynivalenol co-treated with nivalenol] results in increased expression of CXCL8 mRNA [deoxynivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of CXCL8 mRNA [deoxynivalenol co-treated with Zearalenone] results in increased expression of CXCL8 mRNA deoxynivalenol promotes the reaction [nivalenol results in increased expression of CXCL8 mRNA] fumonisin B1 metabolite inhibits the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of CXCL8 mRNA] fumonisin B1 promotes the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of CXCL8 mRNA]

PMID:23688591 PMID:27915442 PMID:30708112
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