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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 14081103
Species: Sus scrofa
RGD Object: Gene
Symbol: BCL2
Name: BCL2 apoptosis regulator
Acc ID: CHEBI:10022
Term: deoxynivalenol
Definition: A trichothecene mycotoxin produced by Fusarium to which wheat, barley, maize (corn) and their products are susceptible to contamination.
Chemical ID: MESH:C007262
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BCL2decreases expressionEXP 6480464CTDdeoxynivalenol results in decreased expression of BCL2 mRNA deoxynivalenol results in decreased expression of BCL2 protein

PMID:25701311 PMID:29109043
BCL2multiple interactionsEXP 6480464CTD[Acetylcysteine co-treated with fumonisin B1 co-treated with deoxynivalenol] results in increased expression of BCL2 protein [Acetylcysteine co-treated with Zearalenone co-treated with deoxynivalenol] results in increased expression of BCL2 protein [fumonisin B1 co-treated with deoxynivalenol] results in decreased expression of BCL2 mRNA [fumonisin B1 co-treated with Zearalenone co-treated with deoxynivalenol] results in decreased expression of BCL2 protein Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in decreased expression of BCL2 mRNA] Acetylcysteine inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 protein] fumonisin B1 inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 protein] fumonisin B1 inhibits the reaction [Zearalenone inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 mRNA]] Zearalenone inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 mRNA] Zearalenone inhibits the reaction [fumonisin B1 inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 protein]]

PMID:29109043
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