Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	14081103
Species:	Sus scrofa
RGD Object:	Gene
Symbol:	BCL2
Name:	BCL2 apoptosis regulator

Acc ID:	CHEBI:10022
Term:	deoxynivalenol
Definition:	A trichothecene mycotoxin produced by Fusarium to which wheat, barley, maize (corn) and their products are susceptible to contamination.
Chemical ID:	MESH:C007262

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
BCL2	decreases expression	EXP		6480464	CTD	deoxynivalenol results in decreased expression of BCL2 mRNA deoxynivalenol results in decreased expression of BCL2 protein	PMID:25701311 PMID:29109043
BCL2	multiple interactions	EXP		6480464	CTD	[Acetylcysteine co-treated with fumonisin B1 co-treated with deoxynivalenol] results in increased expression of BCL2 protein [Acetylcysteine co-treated with Zearalenone co-treated with deoxynivalenol] results in increased expression of BCL2 protein [fumonisin B1 co-treated with deoxynivalenol] results in decreased expression of BCL2 mRNA [fumonisin B1 co-treated with Zearalenone co-treated with deoxynivalenol] results in decreased expression of BCL2 protein Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in decreased expression of BCL2 mRNA] Acetylcysteine inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 protein] fumonisin B1 inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 protein] fumonisin B1 inhibits the reaction [Zearalenone inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 mRNA]] Zearalenone inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 mRNA] Zearalenone inhibits the reaction [fumonisin B1 inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 protein]]	PMID:29109043

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