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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345835
Species: Homo sapiens
RGD Object: Gene
Symbol: EIF2AK2
Name: eukaryotic translation initiation factor 2 alpha kinase 2
Acc ID: CHEBI:10022
Term: deoxynivalenol
Definition: A trichothecene mycotoxin produced by Fusarium to which wheat, barley, maize (corn) and their products are susceptible to contamination.
Chemical ID: MESH:C007262
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
EIF2AK2multiple interactionsEXP 6480464CTDEIF2AK2 protein affects the reaction [deoxynivalenol results in increased activity of RELA protein]; EIF2AK2 protein affects the reaction [deoxynivalenol results in increased expression of CXCL8 mRNA]PMID:18599499
EIF2AK2affects response to substanceISOEif2ak2 (Mus musculus)6480464CTDEIF2AK2 protein affects the susceptibility to deoxynivalenolPMID:22491426
EIF2AK2decreases expressionISOEif2ak2 (Mus musculus)6480464CTDdeoxynivalenol results in decreased expression of EIF2AK2 mRNAPMID:17090620
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