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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 9275041
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kdm6a
Name: lysine demethylase 6A
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kdm6aincreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of KDM6A mRNAPMID:32109520
Kdm6aaffects expressionISOKdm6a (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of KDM6A mRNAPMID:21570461
Kdm6aincreases expressionISOKdm6a (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of KDM6A mRNAPMID:15034205
Kdm6amultiple interactionsISOKdm6a (Mus musculus)6480464CTDAHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of KDM6A mRNA]; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to KDM6A promoter]PMID:15034205 PMID:19654925
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