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GENE - TERM ANNOTATION REPORT

RGD ID: 9034222
Species: Chinchilla lanigera
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1
Acc ID: DOID:9002331
Term: Knee Osteoarthritis
Definition: Noninflammatory degenerative disease of the knee joint consisting of three large categories: conditions that block normal synchronous movement, conditions that produce abnormal pathways of motion, and conditions that cause stress concentration resulting in changes to articular cartilage. (Crenshaw, Campbell's Operative Orthopaedics, 8th ed, p2019)
Definition Source(s): MESH:D020370
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1 ISOESR1 (Homo sapiens)9068941RGDDNA:polymorphisms, haplotype:intron, exonPMID:15380041 REF_RGD_ID:10045840
Esr1 ISOESR1 (Homo sapiens)9068941RGDDNA:repeat:promoter:-1174(TA)9-25 (human)PMID:16098017 REF_RGD_ID:10043199
Esr1 ISOESR1 (Homo sapiens)9068941RGDDNA:SNP:cds:c.1782G>A (rs2228480) (human)PMID:20128071 REF_RGD_ID:10045835
Esr1 ISOESR1 (Homo sapiens)9068941RGDDNA:SNPs:intron: (rs2234693, rs9340799) (human)PMID:24772413 REF_RGD_ID:10045829
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