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GENE - TERM ANNOTATION REPORT

RGD ID: 9018695
Species: Chinchilla lanigera
RGD Object: Gene
Symbol: Ager
Name: advanced glycosylation end-product specific receptor
Acc ID: DOID:10652
Term: Alzheimer's disease
Definition: A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Alzheimer%27s_disease "DO" "DO", http://www.merriam-webster.com/medical/alzheimer%27s%20disease "DO" "DO", http://www.nia.nih.gov/alzheimers/publication/alzheimers-disease-fact-sheet "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ager ISOAger (Rattus norvegicus)9068941RGDprotein:increased expression:hippocampus (rat)PMID:23396166 REF_RGD_ID:7244266
Ager ISOAGER (Homo sapiens)9068941RGD PMID:22415896 REF_RGD_ID:7245561
Ager ISOAGER (Homo sapiens)9068941RGDprotein:increased expression:brain (human)PMID:8751438 REF_RGD_ID:1300365
Ager ISOAger (Mus musculus)9068941RGD PMID:22745485 REF_RGD_ID:6784502
Ager ISOAger (Mus musculus)9068941RGDmRNA:increased expression:hippocampus, cerebral cortex (mouse)PMID:23164356 REF_RGD_ID:7244287
AgertreatmentISOAger (Rattus norvegicus)9068941RGD PMID:23396166 REF_RGD_ID:7244266
AgertreatmentISOAger (Mus musculus)9068941RGD PMID:21593432 REF_RGD_ID:7245965
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