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GENE - TERM ANNOTATION REPORT

RGD ID: 9014263
Species: Chinchilla lanigera
RGD Object: Gene
Symbol: Adm
Name: adrenomedullin
Acc ID: GO:0031623
Term: receptor internalization
Definition: A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.
Definition Source(s): GOC:bf, GOC:mah, GOC:signaling, PMID:15006537, PMID:19643732
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adminvolved_inISOADM (Homo sapiens)9068941UniProt PMID:10882736 PMID:15613468 PMID:20074556

PMID:10882736 PMID:15613468 PMID:20074556
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