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GENE - TERM ANNOTATION REPORT

RGD ID: 9012944
Species: Chinchilla lanigera
RGD Object: Gene
Symbol: Hcn4
Name: hyperpolarization activated cyclic nucleotide gated potassium channel 4
Acc ID: DOID:9007925
Term: Sudden Cardiac Death
Definition: Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as CHEST PAIN and CARDIAC ARRHYTHMIAS, particularly VENTRICULAR TACHYCARDIA, can lead to the loss of consciousness and cardiac arrest followed by biological death. (from Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 7th ed., 2005)
Definition Source(s): MESH:D016757
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hcn4 ISOHCN4 (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Sudden cardiac deathPMID:21615589 PMID:23623143 PMID:23861362 PMID:24033266 PMID:24569893 PMID:25145517 PMID:25467552 PMID:25642760 PMID:25741868 PMID:26467025 PMID:28492532
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