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GENE - TERM ANNOTATION REPORT

RGD ID: 9007606
Species: Chinchilla lanigera
RGD Object: Gene
Symbol: Hgf
Name: hepatocyte growth factor
Acc ID: DOID:13550
Term: angle-closure glaucoma
Definition: A glaucoma characterized by closure of the anterior chamber angle such that aqueous outflow is blocked and the intraocular pressure becomes inappropriately elevated leading to optic nerve damage and visual field loss. Angle-closure glaucoma has_symptom progressive peripheral vision loss, decreased vision, and pain, redness, and headache in acute cases. Angle closure glaucoma can be caused by anatomically narrow angle, injury to the trabecular meshwork, and injuries to the anterior chamber, such as neovascularization and uveitis. (DO)
Definition Source(s): https://en.wikipedia.org/wiki/Glaucoma "DO" "DO", https://eyewiki.aao.org/Primary_vs._Secondary_Angle_Closure_Glaucoma "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HgfsusceptibilityISOHGF (Homo sapiens)9068941RGDDNA:SNPs,haplotype::rs5745718,rs1742817(human)PMID:23585864 REF_RGD_ID:8548548
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