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GENE - TERM ANNOTATION REPORT

RGD ID: 8989701
Species: Chinchilla lanigera
RGD Object: Gene
Symbol: LOC102026028
Name: cytochrome P450 2E1
Acc ID: DOID:11981
Term: morbid obesity
Definition: The condition of weighing two, three, or more times the ideal weight, so called because it is associated with many serious and life-threatening disorders. In the BODY MASS INDEX, morbid obesity is defined as having a BMI greater than 40.0 kg/m2.
Definition Source(s): MESH:D009767
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
LOC102026028 ISOCYP2E1 (Homo sapiens)9068941RGDprotein:increased activity::3x higher activity in morbidly obese subjects compared to non-obese, activity decreased proportionally with weight loss, activity measured as total oral chlorzoxazone clearancePMID:12883487 REF_RGD_ID:1626305
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