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GENE - TERM ANNOTATION REPORT

RGD ID: 8916289
Species: Chinchilla lanigera
RGD Object: Gene
Symbol: App
Name: amyloid beta precursor protein
Acc ID: DOID:10652
Term: Alzheimer's disease
Definition: A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Alzheimer%27s_disease "DO" "DO", http://www.merriam-webster.com/medical/alzheimer%27s%20disease "DO" "DO", http://www.nia.nih.gov/alzheimers/publication/alzheimers-disease-fact-sheet "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AppsusceptibilityISOAPP (Homo sapiens)9068941RGD PMID:16369530 REF_RGD_ID:1599199
ApptreatmentISOApp (Rattus norvegicus)9068941RGDassociated with hypertensionPMID:29568075 REF_RGD_ID:13782047
App ISOAPP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Alzheimer disease | ClinVar Annotator: match by term: Alzheimer disease, early onset | ClinVar Annotator: match by term: Alzheimer disease, protection against | ClinVar Annotator: match by term: Alzheimer's disease | ClinVar Annotator: match by term: Early-Onset Familial Alzheimer DiseasePMID:10097173 PMID:10441572 PMID:10611368 PMID:10631141 PMID:10821838 PMID:11004129 PMID:11063718 PMID:11311152 PMID:11409420 PMID:11441013 PMID:11487570 PMID:11528419 PMID:11568920 PMID:11735772 PMID:11910111 PMID:11978821 PMID:12034808 PMID:12392798 PMID:12552037 PMID:12654973 PMID:12707272 PMID:1303172 PMID:1303239 PMID:1303275 PMID:1307241 PMID:1415269 PMID:14623725 PMID:14769392 PMID:1520398 PMID:15365148 PMID:15488330 PMID:15502844 PMID:15776278 PMID:16033913 PMID:16199547 PMID:1634237 PMID:16369530 PMID:1671712 PMID:1674311 PMID:1678057 PMID:1678058 PMID:1679288 PMID:1679289 PMID:16921174 PMID:16931535 PMID:17576681 PMID:17873282 PMID:18187157 PMID:18234110 PMID:18413473 PMID:18437002 PMID:18667258 PMID:19061884 PMID:1908231 PMID:1925564 PMID:19281847 PMID:19286555 PMID:19363265 PMID:20228223 PMID:20301414 PMID:20452985 PMID:20523046 PMID:2111584 PMID:21210284 PMID:22312439 PMID:22491860 PMID:22503161 PMID:22801501 PMID:23143229 PMID:23224319 PMID:23515184 PMID:23919771 PMID:24033266 PMID:24117942 PMID:24278680 PMID:24390130 PMID:24524897 PMID:24650794 PMID:24677022 PMID:24680827 PMID:24691562 PMID:24694184 PMID:24878480 PMID:25104557 PMID:25138979 PMID:25174650 PMID:25604855 PMID:25617006 PMID:25741868 PMID:25948718 PMID:26104569 PMID:26242991 PMID:26402770 PMID:26467025 PMID:26803359 PMID:27000221 PMID:27312774 PMID:27838006 PMID:27858710 PMID:28304299 PMID:28350801 PMID:28492532 PMID:29263818 PMID:29459625 PMID:29859640 PMID:30279455 PMID:30868685 PMID:31011484 PMID:31557888 PMID:31719132 PMID:31836585 PMID:31914229 PMID:31937505 PMID:32087291 PMID:32345996 PMID:32908482 PMID:32917274 PMID:33268848 PMID:33445953 PMID:35873773 PMID:7611715 PMID:7633445 PMID:7686976 PMID:7806491 PMID:7845465 PMID:8154870 PMID:8191290 PMID:8290965 PMID:8291572 PMID:8410047 PMID:8499923 PMID:8513318 PMID:8577393 PMID:8610157 PMID:8649577 PMID:8863158 PMID:8886002 PMID:9328472 PMID:9536098 PMID:9754958 PMID:9848098
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