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GENE - TERM ANNOTATION REPORT

RGD ID: 8858068
Species: Chinchilla lanigera
RGD Object: Gene
Symbol: Il6r
Name: interleukin 6 receptor
Acc ID: DOID:10652
Term: Alzheimer's disease
Definition: A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Alzheimer%27s_disease "DO" "DO", http://www.merriam-webster.com/medical/alzheimer%27s%20disease "DO" "DO", http://www.nia.nih.gov/alzheimers/publication/alzheimers-disease-fact-sheet "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il6r ISOIL6R (Homo sapiens)9068941RGDDNA:SNPs:promoter, exon:-530G>T, 48867A/>C (p.D358A, rs8192284) (human)PMID:20197062 REF_RGD_ID:10402810
Il6r ISOIL6R (Homo sapiens)9068941RGDprotein:increased expression:cerebrospinal fluid, plasmaPMID:12664314 REF_RGD_ID:10402808
Il6rno_associationISOIL6R (Homo sapiens)9068941RGDDNA:SNPs:promoter:-208G>A (rs4845617) (human)PMID:20197062 REF_RGD_ID:10402810
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