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GENE - TERM ANNOTATION REPORT

RGD ID: 8850929
Species: Chinchilla lanigera
RGD Object: Gene
Symbol: Dicer1
Name: dicer 1, ribonuclease III
Acc ID: DOID:9007071
Term: Hereditary Neoplastic Syndromes
Definition: The condition of a pattern of malignancies within a family, but not every individual's necessarily having the same neoplasm. Characteristically the tumor tends to occur at an earlier than average age, individuals may have more than one primary tumor, the tumors may be multicentric, usually more than 25 percent of the individuals in direct lineal descent from the proband are affected, and the cancer predisposition in these families behaves as an autosomal dominant trait with about 60 percent penetrance.
Definition Source(s): MESH:D009386
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 ISSRGD:119872379068941ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

 
 ISSRGD:119872379068941ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:14528307, PMID:28492532
 ISSRGD:119872379068941ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:15987463, PMID:16095561, PMID:18453628, PMID:21346072, PMID:28492532
 ISSRGD:119872379068941ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:16682203, PMID:28492532
 ISSRGD:119872379068941ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:19556464, PMID:21036787, PMID:22180160, PMID:24839956, PMID:25741868, PMID:26925222, PMID:28492532
 ISSRGD:119872379068941ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:19556464, PMID:21266384, PMID:21882293, PMID:25741868, PMID:26925222, PMID:28492532
 ISSRGD:119872379068941ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:19556464, PMID:21266384, PMID:25741868, PMID:28492532
 ISSRGD:119872379068941ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:19556464, PMID:23728841, PMID:24839956, PMID:25741868, PMID:26925222, PMID:27459524, PMID:28492532
 ISSRGD:119872379068941ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:19556464, PMID:24839956, PMID:25741868, PMID:26925222, PMID:28492532
 ISSRGD:119872379068941ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:19556464, PMID:24909177, PMID:26925222
 ISSRGD:119872379068941ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:19556464, PMID:25022261, PMID:25118636, PMID:26925222, PMID:28492532
 ISSRGD:119872379068941ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:19556464, PMID:25451712, PMID:26886166, PMID:26925222, PMID:28492532
 ISSRGD:119872379068941ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:19556464, PMID:25741868, PMID:26925222, PMID:28323992, PMID:28492532
 ISSRGD:119872379068941ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:19556464, PMID:26822237, PMID:26925222, PMID:28492532
 ISSRGD:119872379068941ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:19556464, PMID:26925222
 ISSRGD:119872379068941ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:19556464, PMID:26925222, PMID:28492532
 ISSRGD:119872379068941ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:21266384, PMID:23547758, PMID:24136150, PMID:24708902, PMID:28492532
 ISSRGD:119872379068941ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:21266384, PMID:24728327, PMID:25741868, PMID:28492532
 ISSRGD:119872379068941ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:21266384, PMID:24728327, PMID:26241669, PMID:28492532
 ISSRGD:119872379068941ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:21266384, PMID:25118636
 ISSRGD:119872379068941ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:21266384, PMID:28492532
 ISSRGD:119872379068941ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:21501861
 ISSRGD:119872379068941ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:22622578
 ISSRGD:119872379068941ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:23547758, PMID:25741868, PMID:28492532
 ISSRGD:119872379068941ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:23620094, PMID:25741868, PMID:28492532
 ISSRGD:119872379068941ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:23620094, PMID:28492532
 ISSRGD:119872379068941ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:23868280
 ISSRGD:119872379068941ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:24033266
 ISSRGD:119872379068941ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:24728327, PMID:25741868, PMID:28492532
 ISSRGD:119872379068941ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:24728327, PMID:28202063, PMID:28492532
 ISSRGD:119872379068941ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:24728327, PMID:28492532
 ISSRGD:119872379068941ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:25022261
 ISSRGD:119872379068941ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:25022261, PMID:25741868
 ISSRGD:119872379068941ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:25670082, PMID:26628006
 ISSRGD:119872379068941ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:25670082, PMID:27527004, PMID:28492532
 ISSRGD:119872379068941ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:25670082, PMID:28492532
 ISSRGD:119872379068941ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:25741868, PMID:28492532
 ISSRGD:119872379068941ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:26526666, PMID:28492532
 ISSRGD:119872379068941ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:26580448, PMID:28492532
 ISSRGD:119872379068941ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:27819237, PMID:28492532
 ISSRGD:119872379068941ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:28012864
 ISSRGD:119872379068941ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome

PMID:28492532
 ISSRGD:119872379068941ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:19556464, PMID:21266384, PMID:28492532
 ISSRGD:119872379068941ClinVarClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary

PMID:25741868
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.