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RGD ID: 8824698
Species: Chinchilla lanigera
RGD Object: Gene
Symbol: Top2b
Name: DNA topoisomerase II beta
Acc ID: PW:0001802
Term: doxorubicin response pathway
Definition: A pathway triggered by administration of doxorubicin, a widely used chemotherapeutic agent. The cytotoxicity of doxorubicin is primarily manifested in its cardiotoxic effect that can lead to heart failure, Possible causes are reactive oxygen species (ROS), impaired iron homeostasis and mitochondrial dysfunction.
Definition Source(s): PMID:25895646
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.