Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - TERM ANNOTATION REPORT

RGD ID: 8816121
Species: Chinchilla lanigera
RGD Object: Gene
Symbol: Il18
Name: interleukin 18
Acc ID: DOID:2841
Term: asthma
Definition: A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing. (DO)
Definition Source(s): http://www.nhlbi.nih.gov/health/dci/Diseases/Asthma/Asthma_WhatIs.html "DO" "DO", https://www.ncbi.nlm.nih.gov/books/NBK430901/ "DO" "DO", https://www.ncbi.nlm.nih.gov/books/NBK7223/ "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il18 ISOIL18 (Homo sapiens)9068941RGD PMID:20497957 REF_RGD_ID:4889898
Il18 ISOIl18 (Mus musculus)9068941RGD PMID:18826499 PMID:20497957 REF_RGD_ID:4889898 REF_RGD_ID:4889908
Il18disease_progressionISOIL18 (Homo sapiens)9068941RGDprotein:increased expression:serumPMID:11174201 REF_RGD_ID:4889863
Il18severityISOIL18 (Homo sapiens)9068941RGDDNA:SNP:promoter: c.-380C>G (rs5744247)(human)PMID:19745201 REF_RGD_ID:4889900
Il18severityISOIL18 (Homo sapiens)9068941RGDDNA:SNPs:Promoter:c. -607C>A (rs1946518), -137G/C (rs187238) (human)PMID:17767553 REF_RGD_ID:4889585
Il18susceptibilityISOIL18 (Homo sapiens)9068941RGDDNA:polymorphism: :c. -105A>C (human)PMID:18200581 REF_RGD_ID:4889910
Il18susceptibilityISOIL18 (Homo sapiens)9068941RGDDNA:SNP:promoter:c.and -137G>C (rs187238)(human)PMID:16433859 REF_RGD_ID:4889923
Go Back to source page   Continue to Ontology report