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GENE - TERM ANNOTATION REPORT

RGD ID: 8798257
Species: Chinchilla lanigera
RGD Object: Gene
Symbol: Nfe2l2
Name: NFE2 like bZIP transcription factor 2
Acc ID: DOID:9006945
Term: Diabetic Cardiomyopathies
Definition: Diabetes complications in which VENTRICULAR REMODELING in the absence of CORONARY ATHEROSCLEROSIS and hypertension results in cardiac dysfunctions, typically LEFT VENTRICULAR DYSFUNCTION. The changes also result in myocardial hypertrophy, myocardial necrosis and fibrosis, and collagen deposition due to impaired glucose tolerance.
Definition Source(s): MESH:D058065
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2amelioratesISONfe2l2 (Mus musculus)9068941RGD PMID:36044268 REF_RGD_ID:156430337
Nfe2l2treatmentISONfe2l2 (Rattus norvegicus)9068941RGDassociated with Diabetes Mellitus, ExperimentalPMID:23453443 REF_RGD_ID:10412713
Nfe2l2treatmentISONfe2l2 (Mus musculus)9068941RGDassociated with Diabetes Mellitus, ExperimentalPMID:23353773 REF_RGD_ID:10412721
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