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GENE - TERM ANNOTATION REPORT

RGD ID: 8783238
Species: Chinchilla lanigera
RGD Object: Gene
Symbol: Ptprf
Name: protein tyrosine phosphatase receptor type F
Acc ID: DOID:9007692
Term: Insulin Resistance
Definition: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
Definition Source(s): MESH:D007333
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptprf ISOPTPRF (Homo sapiens)9068941RGDprotein:increased activity, increased expression:skeletal muscle:activity increased to 140-170% of control in insulin-resistant obese (BMI>30) nondiabetic subjects (p<0.05); activity decreased to 39% in obese NIDDM subjects (p<0.05)PMID:9218523 REF_RGD_ID:1642733
Ptprf ISOPTPRF (Homo sapiens)9068941RGDprotein:increased expression::mouse model overexpressing human transgene, fasting plasma insulin increased 2.5-fold, glucose disposal and uptake into muscle reducedPMID:11309481 REF_RGD_ID:1642735
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