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GENE - TERM ANNOTATION REPORT

RGD ID: 8766123
Species: Chinchilla lanigera
RGD Object: Gene
Symbol: Sirt1
Name: sirtuin 1
Acc ID: DOID:11476
Term: osteoporosis
Definition: A bone resorption disease characterized by decreased density of normally mineralized bone which results_in the thinning of bone tissue and decreased mechanical strength. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Osteoporosis "DO" "DO", http://www.mayoclinic.com/health/osteoporosis/DS00128 "DO" "DO", http://www.niams.nih.gov/Health_Info/Bone/default.asp "DO" "DO", http://www.nlm.nih.gov/medlineplus/ency/article/000360.htm "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sirt1treatmentISOSirt1 (Rattus norvegicus)9068941RGD PMID:22555620 PMID:25377437 REF_RGD_ID:10047129 REF_RGD_ID:10053568
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