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GENE - TERM ANNOTATION REPORT

RGD ID: 8742272
Species: Chinchilla lanigera
RGD Object: Gene
Symbol: Vcp
Name: valosin containing protein
Acc ID: PW:0001361
Term: ataxia telangiectasia-mutated (ATM) signaling pathway
Definition: The ataxia telangiectasia-mutated (ATM) serine/threonine kinase mediated signaling plays a major role in the response to DNA double strand breaks (DSB). Following lesion sensing by the MRN complex, ATM gets activated. Active ATM phosphorylates itself and targets resulting in triggering of DNA repair, cell cycle checkpoint and signaling pathways. While ATM signaling is best documented for its role in DSB responses, evidence accumulates that it functions in a range of other, DNA damage unrelated, responses.
Definition Source(s): PMID:23486281, PMID:23532176
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vcp ISOVCP (Homo sapiens)9068941RGD PMID:24002223 PMID:24326623 REF_RGD_ID:8661237 REF_RGD_ID:8661242
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