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GENE - TERM ANNOTATION REPORT

RGD ID: 8731107
Species: Chinchilla lanigera
RGD Object: Gene
Symbol: Hfe
Name: homeostatic iron regulator
Acc ID: GO:1990712
Term: HFE-transferrin receptor complex
Definition: A protein complex containing at least HFE and a transferrin receptor (either TFR1/TFRC or TFR2), proposed to play a role in the sensing of transferrin-bound Fe (Fe2-Tf) on the plasma membrane to regulate hepcidin transcription.
Definition Source(s): GOC:BHF, GOC:kom, PMID:25147378
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
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