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GENE - TERM ANNOTATION REPORT

RGD ID: 737578
Species: Homo sapiens
RGD Object: Gene
Symbol: SLC11A2
Name: solute carrier family 11 member 2
Acc ID: DOID:11759
Term: hypochromic anemia
Definition: Anemia characterized by a decrease in the ratio of the weight of hemoglobin to the volume of the erythrocyte, i.e., the mean corpuscular hemoglobin concentration is less than normal. The individual cells contain less hemoglobin than they could have under optimal conditions. Hypochromic anemia may be caused by iron deficiency from a low iron intake, diminished iron absorption, or excessive iron loss. It can also be caused by infections or other diseases, therapeutic drugs, lead poisoning, and other conditions. (Stedman, 25th ed; from Miale, Laboratory Medicine: Hematology, 6th ed, p393)
Definition Source(s): MESH:D000747
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SLC11A2 IAGP 1580430RGDDNA:deletion, missense mutation:cds:428_430delGTG, p.G212V (human) 
SLC11A2 ISOSlc11a2 (Rattus norvegicus)729808RGDDNA:missense mutation:cds:p.G185R (human) 
SLC11A2 ISOSlc11a2 (Mus musculus)9743973RGDDNA:missense mutation:cds:p.G185R (human) 
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