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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737577
Species: Homo sapiens
RGD Object: Gene
Symbol: SPN
Name: sialophorin
Acc ID: CHEBI:28819
Term: naringin
Definition: A disaccharide derivative that is (S)-naringenin substituted by a 2-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.
Chemical ID: MESH:C005274
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SPNdecreases expressionISOSpn (Rattus norvegicus)6480464CTDnaringin results in decreased expression of SPN proteinPMID:32428650
SPNincreases expressionISOSpn (Rattus norvegicus)6480464CTDnaringin results in increased expression of SPN proteinPMID:32172062
SPNmultiple interactionsISOSpn (Rattus norvegicus)6480464CTD[bisphenol A co-treated with naringin] results in decreased expression of SPN protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in decreased expression of SPN protein; [NG-Nitroarginine Methyl Ester co-treated with naringin] results in decreased expression of SPN protein; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of SPN protein]; naringin inhibits the reaction [bisphenol A results in increased expression of SPN protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of SPN protein]PMID:32172062 PMID:32428650
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